Antibody treats pediatric brain tumors safely and effectively in mice

Posted By on March 28, 2017

Antibody treats pediatric brain tumors safely and effectively in miceDownload PDF CopyMarch 15, 2017 at 8:21 PMFive types of pediatric brain cancer were safely and effectively treated in mice by an antibody that causes immune cells to engulf and eat tumors without hurting healthy brain cells, according to a new study by researchers at the Stanford University School of Medicine.The immune therapy studied consists of antibodies against a cellular “don’t eat me” signal called CD47. Developed at Stanford, the anti-CD47 antibodies are already being tested in early clinical trials in adults who have tumors outside the central nervous system. But they have never been tried against pediatric brain tumors until now.The new study pitted anti-CD47 antibodies against human cancer cells that had been grown in a dish and implanted in mice. The tests targeted five aggressive pediatric brain tumors: Group 3 medulloblastoma, atypical teratoid rhabdoid tumor, primitive neuroectodermal tumor, pediatric glioblastoma and diffuse intrinsic pontine glioma.”For many of these tumors, there’s just no treatment,” said Samuel Cheshier, MD, PhD, assistant professor of neurosurgery. “Diagnosis is synonymous with a death sentence.”The study will be published March 15 in Science Translational Medicine. Cheshier shares senior authorship of the paper with Irving Weissman, MD, the Virginia and D.K. Ludwig Professor for Clinical Investigation in Cancer Research and professor of pathology and of developmental biology. The lead authors are postdoctoral scholar Sharareh Gholamin, MD, and senior research scientist Siddhartha Mitra, PhD.’Very, very active tumor-killing’Many childhood brain tumors are inoperable. Some also lack effective chemotherapy drugs, or require radiation and chemotherapy so toxic to the developing brain that they cause devastating long-term side effects. In contrast with the toxic profile of existing treatments, the preclinical trials conducted by Cheshier’s team indicate that anti-CD47 antibodies specifically target cancer cells while leaving healthy brain cells alone.”The most exciting aspect of our findings is that no matter what kind of brain tumor we tested it against, this treatment worked really well in the animal models,” said Cheshier, who is also a pediatric neurosurgeon at Lucile Packard Children’s Hospital Stanford. In mice that had been implanted with both normal human brain cells and human brain cancer cells, “there was no toxicity to normal human cells but very, very active tumor-killing in vivo,” he said.Given the encouraging results of the new study and the ongoing research on anti-CD47 antibodies in adults, the antibodies are expected to reach clinical trials in children with brain cancer in one to two years, he added.The anti-CD47 antibodies help the immune system to detect an important difference between cancerous and healthy cells: Cancer cells make “eat me” signals that are displayed on their cell surfaces, while healthy cells do not. However, cancer cells hide these “eat me” signals by producing large quantities of CD47, a “don’t eat me” protein that is found on the surface of both healthy and malignant cells. When CD47 is blocked by antibodies, immune cells called macrophages can detect the cancer cells’ “eat me” signals. Macrophages then selectively target, engulf and destroy the cancer cells without harming healthy cells, because normal cells lack the “eat me” signals.

 

This article has 209 comments

  1. Pingback: cheapest nfl 18 coins ps4 buy

  2. Pingback: Madden 18 news

  3. Pingback: buy cheap Madden Coins

  4. Pingback: buy cheap Madden 18 coins

  5. Pingback: buy cheap Mu Legend Zen

  6. Pingback: cheap MU Legend Zen

  7. Pingback: cheap PoE currency

  8. Pingback: cheap albion online gold

  9. Pingback: madden coins

  10. Pingback: https://www.u4gm.com/path-of-exile

  11. Pingback: air max 270

  12. Pingback: air max 2018

  13. Pingback: jordan 13

  14. Pingback: yeezy shoes

  15. Pingback: michael kors outlet

  16. Pingback: air jordan shoes

  17. Pingback: cheap jordans

  18. Pingback: reebok outlet

  19. Pingback: lebron 16

  20. Pingback: jordan retro

  21. Pingback: air jordan 11

  22. Pingback: jordan shoes

  23. Pingback: adidas ultra boost

  24. Pingback: jordan 11

  25. Pingback: jordan 6

  26. Pingback: air jordans

  27. Pingback: nike epic react flyknit

  28. Pingback: balenciaga shoes

  29. Pingback: longchamp handbags

  30. Pingback: louboutin shoes

  31. Pingback: jordan shoes

  32. Pingback: moncler

  33. Pingback: michael kors outlet

  34. Pingback: coach bags sale

  35. Pingback: adidas gazelle

  36. Pingback: yeezy boost 350

  37. Pingback: curry 6

  38. Pingback: golden goose sneakers

  39. Pingback: balenciaga

  40. Pingback: nike air max 270

  41. Pingback: nike shoes

  42. Pingback: cheap nba jerseys

  43. Pingback: kyrie shoes

  44. Pingback: michael kors handbags

  45. Pingback: deion sanders 1994 san francisco 49ers mitchell ness home red jersey mens

  46. Pingback: calcinha tanga cueca fio dental de mulher

  47. Pingback: 氐賵乇 賲賵囟丞 賲賱丕亘爻 氐賷賮 賱賱賲丨噩亘丕 2019

  48. Pingback: movies

  49. Pingback: marc jacobs easy large cosmetics case

  50. Pingback: calvin klein underwear

  51. Pingback: curry 6

  52. Pingback: nmd

  53. Pingback: trustedmdstorefy.com

  54. Pingback: bofilm

  55. Pingback: nike air vapormax

  56. Pingback: Êîíñóëüòàöèÿ ïñèõîëîãà

  57. Pingback: yeezys

  58. Pingback: topedstoreusa.com

  59. Pingback: nike kyrie 5

  60. Pingback: nike lebron 17

  61. Pingback: yeezy

  62. Pingback: yeezys

  63. Pingback: yeezy boost 350

  64. Pingback: Yeezy UK

  65. Pingback: Nike Outlet

  66. Pingback: Travis Scott jordan 1

  67. Pingback: Yeezy 350

  68. Pingback: Yeezy 350

  69. Pingback: jordan shoes

  70. Pingback: hqcialismht.com

  71. Pingback: viagramdtrustser.com

  72. Pingback: Yeezy Shoes

  73. Pingback: Yeezy

  74. Pingback: Nike Outlet Online

  75. Pingback: sildenafilcitrate.monster

  76. Pingback: sale 銈汇兗銉?姝h鍙栨壉搴?new balance mrl999 ak 銉兗銈儍銉?銈广儖銉笺偒銉?mosaic blue 銉栥儷銉?nb421

  77. Pingback: opaska sportowa w pozna艅

  78. Pingback: michael kors outlet

  79. Pingback: lindamedic.com

  80. Pingback: coach outlet

  81. Pingback: fitflop sale

  82. Pingback: camiseta polo p煤rpura etiqueta negra

  83. Pingback: 讟驻诇讛 诪注专讘诇 讘讟讜谉

  84. Pingback: mercedes benz sls amg coupe a lego creation by malte

  85. Pingback: birkin bag

  86. Pingback: paul smith embroidered button shirt men 13256609 ferogpk

  87. Pingback: nike air max 2018

  88. Pingback: vans outlet

  89. Pingback: 2019 2020 real madrid adidas pes tracksuit black kids

  90. Pingback: stephen curry shoes

  91. Pingback: rick and morty season 3

  92. Pingback: balenciaga shoes

  93. Pingback: gucci personalised iphone case

  94. Pingback: off white nike

  95. Pingback: louboutin shoes

  96. Pingback: goyard handbags

  97. Pingback: yeezy boost 500

  98. Pingback: air jordan

  99. Pingback: nike air max

  100. Pingback: jordan shoes

  101. Pingback: Uggs Official Site

  102. Pingback: jordan 12

  103. Pingback: bape hoodie

  104. Pingback: Yeezy 380

  105. Pingback: air max 90

  106. Pingback: Yeezy Boost 350 V2

  107. Pingback: yeezy boost 350

  108. Pingback: Yeezy 380

  109. Pingback: Yeezys

  110. Pingback: nike huarache

  111. Pingback: Nike Outlet Store

  112. Pingback: coach outlet

  113. Pingback: killer doll costume mens halloween costumes savers

  114. Pingback: 1plus1tv

  115. Pingback: #1plus1

  116. Pingback: 2020

  117. Pingback: kobe sneakers

  118. Pingback: asics gel fit sana mint white training shoes this pair of

  119. Pingback: Yeezy 700

  120. Pingback: peter grimm nadine natural fiber hand woven breezer bucket hat

  121. Pingback: golden goose outlet

  122. Pingback: blue leather coat mens buy leather jackets online at best

  123. Pingback: Watch Movies Online

  124. Pingback: Film 2020

  125. Pingback: Top 10 Best

  126. Pingback: under armour football cleats 11

  127. Pingback: mbt shoes

  128. Pingback: yeezy shoes

  129. Pingback: supreme

  130. Pingback: faux fur slippers womens shoes velvet fluffy shoes gucci bees with small heel

  131. Pingback: Human Races

  132. Pingback: lebron 15

  133. Pingback: womens striped printed cutout racerback waist tie high waisted one piece bathing suit swimsuit

  134. Pingback: michael kors purses

  135. Pingback: gucci grey womens metal sunglasses gold black

  136. Pingback: converse shoes

  137. Pingback: kyrie 3

  138. Pingback: my first night of playing minecraft

  139. Pingback: carhartt wip drift swim trunks

  140. Pingback: nike sneakers

  141. Pingback: silhouette okviri za dioptrijske nao膷ale

  142. Pingback: MLB Shop

  143. Pingback: westbrook shoes

  144. Pingback: human design

  145. Pingback: dizajn cheloveka

  146. Pingback: christian louboutin outlet

  147. Pingback: adidas speedex 16.1 boost black shoes

  148. Pingback: goyard bags

  149. Pingback: formal dresses australia 10 best formal dress shops new

  150. Pingback: kd 10

  151. Pingback: curry 4 shoes

  152. Pingback: kate spade handbags

  153. Pingback: titta snyggt shepherd toffel anders herr sk枚nhet billig

  154. Pingback: 杩崱渚伐瑁呰儗蹇?杩崱渚伐瑁呰儗蹇冨搧鐗?浠锋牸 闃块噷宸村反

  155. Pingback: tights collants adidas

  156. Pingback: gray women pullover v neck slim vest in 2019 sweater vest

  157. Pingback: supreme clothing

  158. Pingback: shop nike red benassi jdi 343880 602 for men in uae

  159. Pingback: air max 2017

  160. Pingback: matchbox 2009 construction dump truck 67 e

  161. Pingback: trailmaker mesh backpack

  162. Pingback: prezzi piumini elisabetta franchi

  163. Pingback: perfect pjs fashion blog

  164. Pingback: NFL Jerseys

  165. Pingback: Yeezy

  166. Pingback: saint laurent cross body bags up to 90 off at tradesy

  167. Pingback: nike air max

  168. Pingback: the best running hats for women

  169. Pingback: brand new paul smith mini cooper iphone 6 6s 7 8 plus x xs max xr case cover

  170. Pingback: yeezy boost 350 v2

  171. Pingback: floris van bommel 10703 02

  172. Pingback: golden goose outlet

  173. Pingback: michael kors handbags outlet

  174. Pingback: greyder erkek sneaker ayakkab lacivert keten

  175. Pingback: human design human design

  176. Pingback: asics gel pulse 6 violet

  177. Pingback: christian louboutin shoes

  178. Pingback: online m missoni outlet store m missoni sneakers designer

  179. Pingback: NBA Jerseys

  180. Pingback: jordan shoes

  181. Pingback: telden rain coats for women waterproof

  182. Pingback: Pandora Online Shop

  183. Pingback: Pandora Jewelry Official Site

  184. Pingback: NBA Jerseys

  185. Pingback: fila femme hauts sweat capuche urban line v锚tements et

  186. Pingback: Yeezy Boost 350 V2

  187. Pingback: kurtka the north face mcmurdo parka tnf black

  188. Pingback: Nike Outlet

  189. Pingback: Pandora Outlet Online

  190. Pingback: vapormax

  191. Pingback: new era oakland raiders nfl black pullover hoodie sweatshirt

  192. Pingback: Pandora Jewelry

  193. Pingback: NBA Jerseys

  194. Pingback: Pandora Canada

  195. Pingback: Human Races

  196. Pingback: przeno艣ne i podgrzewacze producenci i dostawcy

  197. Pingback: moncler

  198. Pingback: Pandora Jewelry

  199. Pingback: yeezy shoes

  200. Pingback: the weeknd h m limited edition xo bomber jacket nwt

  201. Pingback: viagra online

  202. Pingback: generic viagra

  203. Pingback: kd shoes

  204. Pingback: target nahrbtnik like me bel

  205. Pingback: cherkassy film

  206. Pingback: adidas yeezy boost

  207. Pingback: ryobi avvitatore ad impulsi

  208. Pingback: kurtka trekkingowa milo gaja 3l lady blue

  209. Pingback: supreme clothing

Comments are closed.