Mayo Clinic researchers find new experimental drug that shrinks tumors in multiple myeloma patients

Posted By on March 28, 2017

Mayo Clinic researchers find new experimental drug that shrinks tumors in multiple myeloma patientsDownload PDF CopyMarch 8, 2017 at 8:11 PMMayo Clinic researchers have found that an experimental drug, LCL161, stimulates the immune system, leading to tumor shrinkage in patients affected by multiple myeloma. The findings are published in Nature Medicine.Multiple myeloma is a blood cancer that affects plasma cells – white blood cells that normally produce antibodies to fight infection. Rather than produce helpful antibodies, the cancer cells, as they grow, secrete large amounts of a single antibody that accumulate in the body, causing kidney problems and infections.”The drug, LCL161, was initially developed to promote tumor death,” says Marta Chesi, Ph.D., a Mayo Clinic biochemist and lead author of the study of 25 Multiple Myeloma patients. “However, we found that the drug does not kill tumor cells directly. Rather, it makes them more visible to the immune system that recognizes them as foreigner invaders and eliminates them.”Related StoriesEarly detection of colorectal cancer can save livesStudy sheds light on cellular mechanisms that enable prostate cancer cells to form secondary tumoursStudy reveals prevalence of racial disparities in treatment, outcomes of early stage NSCLC patientsMayo Clinic researchers will conduct a follow-up clinical trial of LCL161 in combination with an inhibitor of immune checkpoints that has been widely used in many cancer treatments to evaluate if LCL161 could represent a potential new treatment option.”The model for preclinical studies to predict with great accuracy which drugs would work in the clinic was developed a decade ago,” says Dr. Chesi. “And it has been instrumental in the prioritization of which experimental therapeutics should be tested in patients with multiple myeloma.”The research highlights the importance of studying the effects of drugs not only on the tumor cells in a culture plate, but also on the interaction of the tumor cells with their own microenvironment. The finding that LCL161 is active against multiple myeloma suggests that similar drugs may have broader clinical activity than previously thought.The work of Dr. Chesi and her team reflects Mayo Clinic’s focus to bridge basic science discoveries into clinical trials through collaboration, beginning with unmet patient needs.

Source: Mayo Clinic researchers find new experimental drug that shrinks tumors in multiple myeloma patients

This article has 45 comments

  1. Pingback: Top madden coins xbox one Site

  2. Pingback: cheap Madden 18 coins

  3. Pingback: buy Madden 18 Coins

  4. Pingback: buy cheap Madden 18 coins

  5. Pingback: madden 18 coins

  6. Pingback: PoE orbs

  7. Pingback: buy exalted orbs

  8. Pingback: cheap Mu Legend Zen at

  9. Pingback: poe buy items

  10. Pingback: 2019

  11. Pingback:

  12. Pingback: #macron #Lassalle

  13. Pingback: a2019-2020

  14. Pingback: facebook

  15. Pingback: facebook1

  16. Pingback:

  17. Pingback:

  18. Pingback: bofilm

  19. Pingback: Êîíñóëüòàöèÿ ïñèõîëîãà

  20. Pingback:

  21. Pingback:

  22. Pingback:

  23. Pingback:

  24. Pingback:

  25. Pingback:

  26. Pingback: rick and morty season 3

  27. Pingback: serial

  28. Pingback: 1plus1tv

  29. Pingback: #1plus1

  30. Pingback: Watch Movies Online

  31. Pingback: Film 2020

  32. Pingback: human design

  33. Pingback: dizajn cheloveka

  34. Pingback: 2020

  35. Pingback: koma 2020

  36. Pingback: The-Gentlemen

  37. Pingback: led-2

  38. Pingback: pod-vodoi

  39. Pingback: vk 2020

  40. Pingback: parazity-oskar-2020

  41. Pingback: human design human design

  42. Pingback: DSmlka

  43. Pingback: viagra

  44. Pingback: viagra online

  45. Pingback: +

Comments are closed.